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Combined effects of smoking and peripheral arterial disease on all-cause and cardiovascular disease mortality in a Chinese male cohort

机译:吸烟和外周动脉疾病对中国男性队列中全因和心血管疾病死亡率的综合影响

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摘要

OBJECTIVE: Smoking is a major risk factor for peripheral arterial disease (PAD), and PAD is associated with all-cause and cardiovascular disease (CVD) mortality. The objective of this study was to determine the combined effects of smoking and PAD on all-cause and CVD mortality.METHODS: A total of 1979 males 35 years of age or older were enrolled from eight university-affiliated hospitals in Beijing and Shanghai in 2004, with both smoking status and PAD diagnosis obtained, 1712 of them had complete follow-up data. Mortality data were obtained from all participants between December 2007 and February 2008. Cox proportional hazards models were used to evaluate relative risks (RRs) of all-cause mortality and CVD mortality among different groups.RESULTS: At baseline, the average age of participants was 66.98-years-old (SD = 11.57), prevalence of PAD was 24.0% and 65.4% smoked cigarettes. During the 3-year follow-up, all-cause cumulative mortality rates were 27.9% (PAD/smoker), 26.3% (PAD/nonsmoker), 14.1% (no PAD/smoker), and 14.4% (no PAD/nonsmoker) (P \u3c .001), and CVD cumulative mortality rates were 17.8%, 14.9%, 8.1%, and 7.3%, respectively (P \u3c .001). Compared with the no PAD/nonsmoker subjects, adjusted RR from all-cause mortality in the groups of both PAD/smoker, PAD/nonsmoker, and no PAD/smoker were 1.88 (95% confidence interval [CI], 1.34-2.64), 1.37 (95% CI, 0.85-2.23), and 1.08 (95% CI, 0.79-1.49), respectively. The adjusted RR from CVD mortality was 2.12 (95% CI, 1.37-3.28), 1.55 (95% CI, 0.84-2.86), and 1.13 (95% CI, 0.74-1.71), respectively.CONCLUSION: PAD is a major determinant of mortality. Smoking did not contribute to mortality in this study. Further research is needed.
机译:目的:吸烟是周围动脉疾病(PAD)的主要危险因素,而PAD与全因和心血管疾病(CVD)的死亡率有关。本研究的目的是确定吸烟和PAD对全因和CVD死亡率的综合影响。方法:2004年,北京和上海的八所大学附属医院共招募了1979位年龄在35岁以上的男性。 ,同时获得吸烟状态和PAD诊断,其中1712例具有完整的随访数据。在2007年12月至2008年2月之间从所有参与者获得死亡率数据。使用Cox比例风险模型评估不同组间全因死亡率和CVD死亡率的相对风险(RRs)。结果:在基线时,参与者的平均年龄为66.98岁(SD = 11.57),PAD的流行率为24.0%,抽烟率为65.4%。在3年的随访中,全因累计死亡率分别为27.9%(PAD /不吸烟),26.3%(PAD /不吸烟),14.1%(无PAD /不吸烟)和14.4%(无PAD /不吸烟)。 (P <0.001)和CVD累积死亡率分别为17.8%,14.9%,8.1%和7.3%(P <0.001)。与没有PAD /不吸烟者相比,PAD /不吸烟者,PAD /不吸烟者和没有PAD /不吸烟者的全因死亡率调整后的RR为1.88(95%置信区间[CI],1.34-2.64),分别为1.37(95%CI,0.85-2.23)和1.08(95%CI,0.79-1.49)。 CVD死亡率的调整后RR分别为2.12(95%CI,1.37-3.28),1.55(95%CI,0.84-2.86)和1.13(95%CI,0.74-1.71)。结论:PAD是主要的决定因素。死亡率。在这项研究中,吸烟对死亡率没有贡献。需要进一步的研究。

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